Recombinant Pvs48/45 Antigen Expressed in E. coli Generates Antibodies that Block Malaria Transmission in Anopheles albimanus Mosquitoes
Identifieur interne : 000065 ( Main/Exploration ); précédent : 000064; suivant : 000066Recombinant Pvs48/45 Antigen Expressed in E. coli Generates Antibodies that Block Malaria Transmission in Anopheles albimanus Mosquitoes
Auteurs : Myriam Arévalo-Herrera [Colombie] ; Andrés F. Vallejo [Colombie] ; Kelly Rubiano [Colombie] ; Yezid Solarte [Colombie] ; Catherin Marin [Colombie] ; Angélica Castellanos [Colombie] ; Nora Céspedes [Colombie] ; S Crates Herrera [Colombie]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
Transmission of malaria parasites from humans to
Url:
DOI: 10.1371/journal.pone.0119335
PubMed: 25775466
PubMed Central: 4361554
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recombinant <italic>Pvs</italic>48/45 Antigen Expressed in <italic>E</italic>. <italic>coli</italic> Generates Antibodies that Block Malaria Transmission in <italic>Anopheles albimanus</italic> Mosquitoes</title><author><name sortKey="Arevalo Herrera, Myriam" sort="Arevalo Herrera, Myriam" uniqKey="Arevalo Herrera M" first="Myriam" last="Arévalo-Herrera">Myriam Arévalo-Herrera</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Malaria Vaccine and Drug Development Center, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Malaria Vaccine and Drug Development Center, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>School of Health, Universidad del Valle, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>School of Health, Universidad del Valle, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation></author><author><name sortKey="Vallejo, Andres F" sort="Vallejo, Andres F" uniqKey="Vallejo A" first="Andrés F." last="Vallejo">Andrés F. Vallejo</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Caucaseco Scientific Research Center, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Caucaseco Scientific Research Center, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation></author><author><name sortKey="Rubiano, Kelly" sort="Rubiano, Kelly" uniqKey="Rubiano K" first="Kelly" last="Rubiano">Kelly Rubiano</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Malaria Vaccine and Drug Development Center, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Malaria Vaccine and Drug Development Center, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Caucaseco Scientific Research Center, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Caucaseco Scientific Research Center, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation></author><author><name sortKey="Solarte, Yezid" sort="Solarte, Yezid" uniqKey="Solarte Y" first="Yezid" last="Solarte">Yezid Solarte</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>School of Health, Universidad del Valle, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>School of Health, Universidad del Valle, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation></author><author><name sortKey="Marin, Catherin" sort="Marin, Catherin" uniqKey="Marin C" first="Catherin" last="Marin">Catherin Marin</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Primates Center Foundation, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Primates Center Foundation, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation></author><author><name sortKey="Castellanos, Angelica" sort="Castellanos, Angelica" uniqKey="Castellanos A" first="Angélica" last="Castellanos">Angélica Castellanos</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Primates Center Foundation, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Primates Center Foundation, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation></author><author><name sortKey="Cespedes, Nora" sort="Cespedes, Nora" uniqKey="Cespedes N" first="Nora" last="Céspedes">Nora Céspedes</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Malaria Vaccine and Drug Development Center, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Malaria Vaccine and Drug Development Center, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation></author><author><name sortKey="Herrera, S Crates" sort="Herrera, S Crates" uniqKey="Herrera S" first="S 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id="aff003"><addr-line>School of Health, Universidad del Valle, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>School of Health, Universidad del Valle, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation></author><author><name sortKey="Vallejo, Andres F" sort="Vallejo, Andres F" uniqKey="Vallejo A" first="Andrés F." last="Vallejo">Andrés F. Vallejo</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Caucaseco Scientific Research Center, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Caucaseco Scientific Research Center, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation></author><author><name sortKey="Rubiano, Kelly" sort="Rubiano, Kelly" uniqKey="Rubiano K" first="Kelly" last="Rubiano">Kelly Rubiano</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Malaria Vaccine and Drug Development Center, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Malaria Vaccine and Drug Development Center, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Caucaseco Scientific Research Center, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Caucaseco Scientific Research Center, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation></author><author><name sortKey="Solarte, Yezid" sort="Solarte, Yezid" uniqKey="Solarte Y" first="Yezid" last="Solarte">Yezid Solarte</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>School of Health, Universidad del Valle, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>School of Health, Universidad del Valle, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation></author><author><name sortKey="Marin, Catherin" sort="Marin, Catherin" uniqKey="Marin C" first="Catherin" last="Marin">Catherin Marin</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Primates Center Foundation, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Primates Center Foundation, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation></author><author><name sortKey="Castellanos, Angelica" sort="Castellanos, Angelica" uniqKey="Castellanos A" first="Angélica" last="Castellanos">Angélica Castellanos</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Primates Center Foundation, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Primates Center Foundation, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation></author><author><name sortKey="Cespedes, Nora" sort="Cespedes, Nora" uniqKey="Cespedes N" first="Nora" last="Céspedes">Nora Céspedes</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Malaria Vaccine and Drug Development Center, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Malaria Vaccine and Drug Development Center, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation></author><author><name sortKey="Herrera, S Crates" sort="Herrera, S Crates" uniqKey="Herrera S" first="S Crates" last="Herrera">S Crates Herrera</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Malaria Vaccine and Drug Development Center, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Malaria Vaccine and Drug Development Center, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Caucaseco Scientific Research Center, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Caucaseco Scientific Research Center, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Primates Center Foundation, Cali, Colombia</addr-line></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Primates Center Foundation, Cali</wicri:regionArea><wicri:noRegion>Cali</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Transmission of malaria parasites from humans to <italic>Anopheles</italic> mosquitoes can be inhibited by specific antibodies elicited during malaria infection, which target surface <italic>Plasmodium</italic> gametocyte/gamete proteins. Some of these proteins may have potential for vaccine development. <italic>Pvs</italic>48/45 is a <italic>P</italic>. <italic>vivax</italic> gametocyte surface antigen orthologous to <italic>Pfs</italic>48/45, which may play a role during parasite fertilization and thus has potential for transmission blocking (TB) activity. Here we describe the expression of a recombinant <italic>Pvs</italic>48/45 protein expressed in <italic>Escherichia coli</italic> as a ∼60kDa construct which we tested for antigenicity using human sera and for its immunogenicity and transmission blocking activity of specific anti-mouse and anti-monkey <italic>Pvs</italic>48/45 antibodies. The protein reacted with sera of individuals from malaria-endemic areas and in addition induced specific IgG antibody responses in BALB/c mice and <italic>Aotus l</italic>. <italic>griseimembra</italic> monkeys. Sera from both immunized animal species recognized native <italic>P</italic>. <italic>vivax</italic> protein in Western blot (WB) and immunofluorescence assays. Moreover, sera from immunized mice and monkeys produced significant inhibition of parasite transmission to <italic>An</italic>. <italic>Albimanus</italic> mosquitoes as shown by membrane feeding assays. Results indicate the presence of reactive epitopes in the <italic>Pvs</italic>48/45 recombinant product that induce antibodies with TB activity. Further testing of this protein is ongoing to determine its vaccine potential.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Baird, J" uniqKey="Baird J">J Baird</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snow, Rw" uniqKey="Snow R">RW Snow</name></author><author><name sortKey="Omumbo, Ja" uniqKey="Omumbo J">JA Omumbo</name></author><author><name sortKey="Lowe, B" uniqKey="Lowe B">B Lowe</name></author><author><name sortKey="Molyneux, Cs" uniqKey="Molyneux C">CS Molyneux</name></author><author><name sortKey="Obiero, J O" uniqKey="Obiero J">J-O Obiero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doolan, Dl" uniqKey="Doolan D">DL Doolan</name></author><author><name sortKey="Dobano, C" uniqKey="Dobano C">C Dobano</name></author><author><name sortKey="Baird, Jk" uniqKey="Baird J">JK 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uniqKey="Coetzer T">TL Coetzer</name></author><author><name sortKey="Hoppe, Hc" uniqKey="Hoppe H">HC Hoppe</name></author><author><name sortKey="Human, E" uniqKey="Human E">E Human</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Colombie</li></country></list><tree><country name="Colombie"><noRegion><name sortKey="Arevalo Herrera, Myriam" sort="Arevalo Herrera, Myriam" uniqKey="Arevalo Herrera M" first="Myriam" last="Arévalo-Herrera">Myriam Arévalo-Herrera</name></noRegion><name sortKey="Arevalo Herrera, Myriam" sort="Arevalo Herrera, Myriam" uniqKey="Arevalo Herrera M" first="Myriam" last="Arévalo-Herrera">Myriam Arévalo-Herrera</name><name sortKey="Castellanos, Angelica" sort="Castellanos, Angelica" uniqKey="Castellanos A" first="Angélica" last="Castellanos">Angélica Castellanos</name><name sortKey="Cespedes, Nora" sort="Cespedes, Nora" uniqKey="Cespedes N" first="Nora" last="Céspedes">Nora Céspedes</name><name sortKey="Herrera, S Crates" sort="Herrera, S Crates" uniqKey="Herrera S" first="S Crates" last="Herrera">S Crates Herrera</name><name sortKey="Herrera, S Crates" sort="Herrera, S Crates" uniqKey="Herrera S" first="S Crates" last="Herrera">S Crates Herrera</name><name sortKey="Herrera, S Crates" sort="Herrera, S Crates" uniqKey="Herrera S" first="S Crates" last="Herrera">S Crates Herrera</name><name sortKey="Marin, Catherin" sort="Marin, Catherin" uniqKey="Marin C" first="Catherin" last="Marin">Catherin Marin</name><name sortKey="Rubiano, Kelly" sort="Rubiano, Kelly" uniqKey="Rubiano K" first="Kelly" last="Rubiano">Kelly Rubiano</name><name sortKey="Rubiano, Kelly" sort="Rubiano, Kelly" uniqKey="Rubiano K" first="Kelly" last="Rubiano">Kelly Rubiano</name><name sortKey="Solarte, Yezid" sort="Solarte, Yezid" uniqKey="Solarte Y" first="Yezid" last="Solarte">Yezid Solarte</name><name sortKey="Vallejo, Andres F" sort="Vallejo, Andres F" uniqKey="Vallejo A" first="Andrés F." last="Vallejo">Andrés F. 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